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Home >> Specialities >> Kidney Transplant >> Goodpasture’s Syndrome

Goodpasture’s Syndrome

Goodpasture’s Syndrome, also known as Anti-GBM disease, is a rare autoimmune disorder in which the body starts to attack 2 of the most vital organs, i.e. the lungs and the kidneys. A patient suffering from the condition usually presents with pulmonary haemorrhage and glomerulonephritis. It is most commonly seen in people who are in their 20s or those who are above 60. Men are more susceptible to Goodpasture’s syndrome as compared to women. The condition can prove to be potentially life-threatening without timely medical intervention.
What causes Goodpasture’s Syndrome?
Goodpasture's Syndrome is an autoimmune disorder in which a person's immune system attacks the healthy tissues in the lungs and kidneys. It is marked by the development of collagen in tiny air sacs and glomeruli in the lungs and kidneys, respectively. The exact cause of this is unknown; however, it is believed to be caused by a respiratory infection or inhalation of hydrocarbon solvents. 

What are the symptoms of Goodpasture’s Syndrome?
A patient suffering from Goodpasture's syndrome experiences a combination of both pulmonary and renal symptoms. These include:

  • Hematuria
  • Anaemia
  • Decreased urine output
  • Hypertension 
  • Nausea and vomiting 
  • Breathing difficulties
  • Chest pain or angina
  • Persistent cough 
  • Fatigue and weakness
  • Fever and malaise 
  • Nasal bleeding 
  • Pale tone of the skin
  • Coughing up blood 

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